2. Signaling Pathways
  3. PROTAC
  4. Ligands for E3 Ligase
  5. Ligands for E3 Ligase Degrader

Ligands for E3 Ligase Degrader

Ligands for E3 Ligase Isoform Comparison

Ligands for E3 Ligase Degraders (2):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-161668
    Ru-Poma
    Ru-Poma is a Ru(II)-based photosensitizer, which attenuates Cisplatin (HY-17394)-resistant tumor through photodynamic therapy (PDT). Ru-Poma photodegrades CRBN through a Pomalidomide (HY-10984) moiety. Ru-Poma induces ferroptosis, through an increase in lipid peroxide, downregulation of GPX4 and GAPDH expression. Ru-Poma exhibits cytotoxicity in A549, with IC50 of 18.46 μM and 0.37 μM in dark and upon irradiation, respectively.
    Ru-Poma
  • HY-164550
    YF438 2247210-09-7
    YF438 is an HDAC inhibitor with effective anticancer activity both in vitro and in vivo. YF438 inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2-MDMX, and promoting the degradation of MDM2.
    YF438